Kuroda - Laboratory
アシック ミルザ フセイン
Aashiq Mirza Hussain
略歴
- 2006年~2006年
- Research Assistant, Institute of Genomics and Integrative Biology, New Delhi, India.
- 2007年~2008年
- Senior Research Associate, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
- 2008年~2010年
- Research Assistant, Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA.
- 2010年~2011年
- Visiting Pre-doctoral Fellow, Tokyo Medical University, Tokyo, Japan.
- 2012年~2016年
- PhD in University of Copenhagen, Copenhagen, Denmark.
- 2015年~2016年
- Postdoctoral Associate, Copenhagen Diabetes Research Center, Copenhagen, Denmark
- 2015年~
- Consultant, Cancer Biomarker Discovery & Development, AcuaMark Diagnostics, New York, NY, USA.
- 2016年~2018年
- Postdoctoral Associate, Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA.
- 2018年~
- Postdoctoral Associate, Pharmacology, Weill Cornell Medicine, New York, NY, USA.
- 2019年~
- Associate Professor, Molecular Pathology, Tokyo Medical University.
学位
Ph.D. Cellular and Genetic Medicine
M.S. Biotechnology
所属学会・委員
New York Academy of Sciences
Danish RNA Society
助成金
- 2018年~2020年
- Postdoctoral Fellowship, The Ruth L. Kirschstein NRSA, NCI, Cancer Pharmacology Training (T32) Grant, USA.
- 2015年~2016年
- Independent Research Award, Aase og Ejnar Danielsens Fond, Denmark.
- 2012年~2015年
- Pre-Doctoral Fellowship, Danish Council for Independent Research, Denmark.
- 2013年~2014年
- Pre-Doctoral Research Fellowship, Poul and Erna Sehested Hansen Foundation, Denmark.
- 2010年~2011年
- Pre-doctoral Fellowship, Heiwajima Foundation, Tokyo, Japan.
業績
学会発表
- 2014年
- Transcriptome profiling of lncRNAs in Crohn’s disease and ulcerative colitis; (Abstract A26). Oral presentation delivered at the Herlev University Hospital Research Day, Copenhagen, Denmark.
- 2014年
- Transcriptome profiling of lncRNAs reveal distinctive expression signatures in Crohn’s Disease and Ulcerative Colitis. Oral presentation delivered at the 12th Herbstseminar der Bioinformatik, Doubice, Czech Republic.
- 2014年
- Expression analysis of structured-RNA candidates in Autoimmune and Inflammatory Diseases. Oral presentation delivered at the 29th TBI Winter Seminar, Bled, Slovenia.
- 2013年
- Human breast milk derived exosomes from type 1 diabetic mothers deliver functional RNA to the infant. Poster presentation delivered at the CSHL Meeting: Eukaryotic mRNA Processing, CSHL, New York.
- 2013年
- Non-coding RNAs in Autoimmune and Inflammatory Diseases. Oral presentation delivered at the 28th TBI Winterseminar, Bled, Slovenia.
原著
- Mirza AH, Kaur S, Nielsen LB, Størling J, Yarani R, Roursgaard M, Mathiesen ER, Damm P, Svare J, Mortensen HB, Pociot F.
Breast Milk-Derived Extracellular Vesicles Enriched in Exosomes From Mothers With
Type 1 Diabetes Contain Aberrant Levels of microRNAs. Front Immunol. 2019 Oct 25;10:2543.
doi: 10.3389/fimmu.2019.02543. eCollection 2019.
- S Yasmeen, S Kaur, AH Mirza, B Brodin, F Pociot, C Kruuse.
miRNA-27a-3p and miRNA-222-3p as Novel Modulators of Phosphodiesterase 3a (PDE3A) in Cerebral Microvascular Endothelial Cells.
Molecular neurobiology, 1-11. 2019.
- S Kaur, A Mirza, F Pociot. Cell Type-Selective Expression of Circular RNAs in Human Pancreatic Islets.
Non-coding RNA 4 (4), 38. 2018.
- Nasim Samandari, Aashiq Mirza, Simranjeet Kaur, Philip Hougaard, Lotte Nielsen, Siri Fredheim, Henrik Mortensen, Flemming Pociot.
Influence of Disease Duration on Circulating Levels of miRNAs in Children and Adolescents with New Onset Type 1 Diabetes.
Non-coding RNA 4 (4), 35. 2018.
- Mirza AH, Das S, Pingle MR, Rundell MS, Armah G, Gyan B, Hodinka RL, Larone DH, Spitzer ED, Barany F,
Golightly LM. A Multiplex PCR/LDR Assay for Viral Agents of Diarrhea with the Capacity to Genotype Rotavirus. Sci Rep.
2018 Sep 4;8(1):13215.
- Nielsen KO, Jacobsen KS, Mirza AH, Winther TN, Størling J, Glebe D, Pociot F, Hogh B.
Hepatitis B virus upregulates host microRNAs that target apoptosis-regulatory genes in an in vitro cell model.
Exp Cell Res. 2018 Oct 1;371(1):92-103.
- Nielsen KO, Mirza AH, Kaur S, Jacobsen KS, Winther TN, Glebe D, Pociot F, Hogh B, Størling J.
Hepatitis B virus suppresses the secretion of insulin-like growth factor binding protein 1 to facilitate anti-apoptotic
IGF-1 effects in HepG2 cells. Exp Cell Res. 2018 Sep 15;370(2):399-408.
- Aashiq H. Mirza, Simranjeet Kaur, Flemming Pociot. Long non-coding RNAs as novel players in β cell
function and type 1 diabetes.
Human Genomics. 2017 Jul 24;11(1):17.
- Stefan E Seemann, Aashiq H Mirza, Claus Hansen, Claus H Bang-Berthelsen, Christian Garde, Mikkel Christensen-Dalsgaard,
Elfar Torarinsson, Zizhen Yao, Christopher T Workman, Flemming Pociot, Henrik Nielsen, Niels Tommerup, Walter L
Ruzzo, Jan Gorodkin. The identification and functional annotation of RNA structures conserved in vertebrates.
Genome Res. 2017 Aug;27(8):1371-1383.
- Nasim Samandari1, Aashiq H. Mirza, Lotte B. Nielsen, Simranjeet Kaur, Philip Hougaard, Siri Fredheim1, Henrik B.
Mortensen, Flemming Pociot. Circulating microRNA levels predict residual beta-cell function and glycaemic control
in children with type 1 diabetes mellitus. Diabetologia. 2016 Nov 19.
- Kaur S, Mirza AH, Brorsson CA, Fløyel T, Størling J, Mortensen HB, Pociot F; Hvidoere International Study Group.
The genetic and regulatory architecture of ERBB3-type 1 diabetes susceptibility locus. Mol Cell Endocrinol.
2015 Oct 9. pii:S0303-7207(15)30103-9.
- Das S, Rundell MS, Mirza AH, Pingle MR, Shigyo K, Garrison AR, Paragas J, Smith SK, Olson VA, Larone DH, Spitzer ED,
Barany F, Golightly LM. A Multiplex PCR/LDR Assay for the Simultaneous
Identification of Category A Infectious Pathogens: Agents of Viral Hemorrhagic Fever and Variola Virus.
PLoS One. 2015 Sep 18;10(9):e0138484.
- Mirza AH, Berthelsen CH, Seemann SE, Pan X, Frederiksen KS, Vilien M, Gorodkin J, Pociot F.
Transcriptomic landscape of lncRNAs in inflammatory bowel disease. Genome Med. 2015 May 13;7(1):39.
- Mirza AH, Kaur S, Brorsson CA, Pociot F. Effects of GWAS-associated genetic variants on lncRNAs within IBD
and T1D candidate loci. PLoS One. 2014 Aug 21;9(8):e105723.
- Winther TN, Jacobsen KS, Mirza AH, Heiberg IL, Bang-Berthelsen CH, Pociot F, Hogh B. Circulating MicroRNAs
in Plasma of Hepatitis B e Antigen Positive Children Reveal Liver-Specific Target Genes. Int J Hepatol. 2014:791045.
- Rundell MS, Pingle M, Das S, Hussain A, Ocheretina O, Charles M, Larone DH, Spitzer ED, Golightly L, Barany F.
A multiplex PCR/LDR assay for simultaneous detection and identification of the NIAID category B bacterial
food and water-borne pathogens. Diagn Microbiol Infect Dis. 2014 Jun;79(2):135-40.
- Goswami R, Singh A, Gupta N, Indian Genome Variation Consortium, Rani R.
Presence of strong association of the major histocompatibility complex (MHC)
class I allele HLA-A*26:01 with idiopathic hypoparathyroidism. J Clin Endocrinol Metab. 2012, 97(9):E1820-4.
- Suzuki R, Tanaka M, Takanashi M, Hussain A, Yuan B, Toyoda H, Kuroda M;
Anthocyanidins-enriched bilberry extracts inhibit 3T3-L1 adipocyte differentiation
via the insulin pathway. Nutr Metab (Lond). 2011 Mar 8;8:14.
- Aggarwal S, Negi S, Jha P, Singh PK, Stobdan T, Pasha MA, Ghosh S, Agrawal A, Indian Genome Variation Consortium,
Prasher B, Mukerji M. EGLN1 involvement in high-altitude adaptation revealed through genetic analysis of
extreme constitution types defined in Ayurveda. Proc Natl Acad Sci U S A. 2010, 107(44):18961-6.
- D.Kaul, A.Hussain; Cellular AATF gene encodes a novel miRNA that can contribute to HIV-1 latency. IJBB,
Vol.46, June 2009,pp.237-240.
- Indian Genome Variation Consortium. Genetic landscape of the people of India: a canvas for disease
gene exploration. J Genet. 2008, 87(1):3-20.
総説
- X Pan, Y Yang, CQ Xia, AH Mirza, HB Shen. Recent methodology progress of deep learning for
RNA–protein interaction prediction. Wiley Interdisciplinary Reviews: RNA, e1544.
- R Yarani, AH Mirza, S Kaur, F Pociot. The emerging role of lncRNAs in inflammatory bowel disease.
Experimental & molecular medicine 50 (12), 161. 2018.
その他
- 2017年
- Interview: Aashiq Mirza on the importance of being collaborative for a successful career in academic research. Decoding Life Series. Genes to Genomes. Genetics Society of America.
http://genestogenomes.org/aashiq-mirza-on-the-importance-of-being-collaborative/