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Aashiq Mirza Hussain

兼任准教授
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略歴
2006年~2006年
Research Assistant, Institute of Genomics and Integrative Biology, New Delhi, India.
2007年~2008年
Senior Research Associate, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
2008年~2010年
Research Assistant, Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA.
2010年~2011年
Visiting Pre-doctoral Fellow, Tokyo Medical University, Tokyo, Japan.
2012年~2016年
PhD in University of Copenhagen, Copenhagen, Denmark.
2015年~2016年
Postdoctoral Associate, Copenhagen Diabetes Research Center, Copenhagen, Denmark
2015年~
Consultant, Cancer Biomarker Discovery & Development, AcuaMark Diagnostics, New York, NY, USA.
2016年~2018年
Postdoctoral Associate, Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA.
2018年~
Postdoctoral Associate, Pharmacology, Weill Cornell Medicine, New York, NY, USA.
2019年~
Associate Professor, Molecular Pathology, Tokyo Medical University.
学位
Ph.D. Cellular and Genetic Medicine
M.S. Biotechnology
所属学会・委員
New York Academy of Sciences
Danish RNA Society
助成金
2018年~2020年
Postdoctoral Fellowship, The Ruth L. Kirschstein NRSA, NCI, Cancer Pharmacology Training (T32) Grant, USA.
2015年~2016年
Independent Research Award, Aase og Ejnar Danielsens Fond, Denmark.
2012年~2015年
Pre-Doctoral Fellowship, Danish Council for Independent Research, Denmark.
2013年~2014年
Pre-Doctoral Research Fellowship, Poul and Erna Sehested Hansen Foundation, Denmark.
2010年~2011年
Pre-doctoral Fellowship, Heiwajima Foundation, Tokyo, Japan.
​業績
学会発表
2014年
Transcriptome profiling of lncRNAs in Crohn’s disease and ulcerative colitis; (Abstract A26). Oral presentation delivered at the Herlev University Hospital Research Day, Copenhagen, Denmark.
2014年
Transcriptome profiling of lncRNAs reveal distinctive expression signatures in Crohn’s Disease and Ulcerative Colitis. Oral presentation delivered at the 12th Herbstseminar der Bioinformatik, Doubice, Czech Republic.
2014年
Expression analysis of structured-RNA candidates in Autoimmune and Inflammatory Diseases. Oral presentation delivered at the 29th TBI Winter Seminar, Bled, Slovenia.
2013年
Human breast milk derived exosomes from type 1 diabetic mothers deliver functional RNA to the infant. Poster presentation delivered at the CSHL Meeting: Eukaryotic mRNA Processing, CSHL, New York.
2013年
Non-coding RNAs in Autoimmune and Inflammatory Diseases. Oral presentation delivered at the 28th TBI Winterseminar, Bled, Slovenia.
原著
  • Mirza AH, Kaur S, Nielsen LB, Størling J, Yarani R, Roursgaard M, Mathiesen ER, Damm P, Svare J, Mortensen HB, Pociot F. Breast Milk-Derived Extracellular Vesicles Enriched in Exosomes From Mothers With Type 1 Diabetes Contain Aberrant Levels of microRNAs. Front Immunol. 2019 Oct 25;10:2543. doi: 10.3389/fimmu.2019.02543. eCollection 2019.
  • S Yasmeen, S Kaur, AH Mirza, B Brodin, F Pociot, C Kruuse. miRNA-27a-3p and miRNA-222-3p as Novel Modulators of Phosphodiesterase 3a (PDE3A) in Cerebral Microvascular Endothelial Cells. Molecular neurobiology, 1-11. 2019.
  • S Kaur, A Mirza, F Pociot. Cell Type-Selective Expression of Circular RNAs in Human Pancreatic Islets. Non-coding RNA 4 (4), 38. 2018.
  • Nasim Samandari, Aashiq Mirza, Simranjeet Kaur, Philip Hougaard, Lotte Nielsen, Siri Fredheim, Henrik Mortensen, Flemming Pociot. Influence of Disease Duration on Circulating Levels of miRNAs in Children and Adolescents with New Onset Type 1 Diabetes. Non-coding RNA 4 (4), 35. 2018.
  • Mirza AH, Das S, Pingle MR, Rundell MS, Armah G, Gyan B, Hodinka RL, Larone DH, Spitzer ED, Barany F, Golightly LM. A Multiplex PCR/LDR Assay for Viral Agents of Diarrhea with the Capacity to Genotype Rotavirus. Sci Rep. 2018 Sep 4;8(1):13215.
  • Nielsen KO, Jacobsen KS, Mirza AH, Winther TN, Størling J, Glebe D, Pociot F, Hogh B. Hepatitis B virus upregulates host microRNAs that target apoptosis-regulatory genes in an in vitro cell model. Exp Cell Res. 2018 Oct 1;371(1):92-103.
  • Nielsen KO, Mirza AH, Kaur S, Jacobsen KS, Winther TN, Glebe D, Pociot F, Hogh B, Størling J. Hepatitis B virus suppresses the secretion of insulin-like growth factor binding protein 1 to facilitate anti-apoptotic IGF-1 effects in HepG2 cells. Exp Cell Res. 2018 Sep 15;370(2):399-408.
  • Aashiq H. Mirza, Simranjeet Kaur, Flemming Pociot. Long non-coding RNAs as novel players in β cell function and type 1 diabetes. Human Genomics. 2017 Jul 24;11(1):17.
  • Stefan E Seemann, Aashiq H Mirza, Claus Hansen, Claus H Bang-Berthelsen, Christian Garde, Mikkel Christensen-Dalsgaard, Elfar Torarinsson, Zizhen Yao, Christopher T Workman, Flemming Pociot, Henrik Nielsen, Niels Tommerup, Walter L Ruzzo, Jan Gorodkin. The identification and functional annotation of RNA structures conserved in vertebrates. Genome Res. 2017 Aug;27(8):1371-1383.
  • Nasim Samandari1, Aashiq H. Mirza, Lotte B. Nielsen, Simranjeet Kaur, Philip Hougaard, Siri Fredheim1, Henrik B. Mortensen, Flemming Pociot. Circulating microRNA levels predict residual beta-cell function and glycaemic control in children with type 1 diabetes mellitus. Diabetologia. 2016 Nov 19.
  • Kaur S, Mirza AH, Brorsson CA, Fløyel T, Størling J, Mortensen HB, Pociot F; Hvidoere International Study Group. The genetic and regulatory architecture of ERBB3-type 1 diabetes susceptibility locus. Mol Cell Endocrinol. 2015 Oct 9. pii:S0303-7207(15)30103-9.
  • Das S, Rundell MS, Mirza AH, Pingle MR, Shigyo K, Garrison AR, Paragas J, Smith SK, Olson VA, Larone DH, Spitzer ED, Barany F, Golightly LM. A Multiplex PCR/LDR Assay for the Simultaneous Identification of Category A Infectious Pathogens: Agents of Viral Hemorrhagic Fever and Variola Virus.
    PLoS One. 2015 Sep 18;10(9):e0138484.
  • Mirza AH, Berthelsen CH, Seemann SE, Pan X, Frederiksen KS, Vilien M, Gorodkin J, Pociot F. Transcriptomic landscape of lncRNAs in inflammatory bowel disease. Genome Med. 2015 May 13;7(1):39.
  • Mirza AH, Kaur S, Brorsson CA, Pociot F. Effects of GWAS-associated genetic variants on lncRNAs within IBD and T1D candidate loci. PLoS One. 2014 Aug 21;9(8):e105723.
  • Winther TN, Jacobsen KS, Mirza AH, Heiberg IL, Bang-Berthelsen CH, Pociot F, Hogh B. Circulating MicroRNAs in Plasma of Hepatitis B e Antigen Positive Children Reveal Liver-Specific Target Genes. Int J Hepatol. 2014:791045.
  • Rundell MS, Pingle M, Das S, Hussain A, Ocheretina O, Charles M, Larone DH, Spitzer ED, Golightly L, Barany F. A multiplex PCR/LDR assay for simultaneous detection and identification of the NIAID category B bacterial food and water-borne pathogens. Diagn Microbiol Infect Dis. 2014 Jun;79(2):135-40.
  • Goswami R, Singh A, Gupta N, Indian Genome Variation Consortium, Rani R. Presence of strong association of the major histocompatibility complex (MHC) class I allele HLA-A*26:01 with idiopathic hypoparathyroidism. J Clin Endocrinol Metab. 2012, 97(9):E1820-4.
  • Suzuki R, Tanaka M, Takanashi M, Hussain A, Yuan B, Toyoda H, Kuroda M; Anthocyanidins-enriched bilberry extracts inhibit 3T3-L1 adipocyte differentiation via the insulin pathway. Nutr Metab (Lond). 2011 Mar 8;8:14.
  • Aggarwal S, Negi S, Jha P, Singh PK, Stobdan T, Pasha MA, Ghosh S, Agrawal A, Indian Genome Variation Consortium, Prasher B, Mukerji M. EGLN1 involvement in high-altitude adaptation revealed through genetic analysis of extreme constitution types defined in Ayurveda. Proc Natl Acad Sci U S A. 2010, 107(44):18961-6.
  • D.Kaul, A.Hussain; Cellular AATF gene encodes a novel miRNA that can contribute to HIV-1 latency. IJBB, Vol.46, June 2009,pp.237-240.
  • Indian Genome Variation Consortium. Genetic landscape of the people of India: a canvas for disease gene exploration. J Genet. 2008, 87(1):3-20.
総説
  • X Pan, Y Yang, CQ Xia, AH Mirza, HB Shen. Recent methodology progress of deep learning for RNA–protein interaction prediction. Wiley Interdisciplinary Reviews: RNA, e1544.
  • R Yarani, AH Mirza, S Kaur, F Pociot. The emerging role of lncRNAs in inflammatory bowel disease. Experimental & molecular medicine 50 (12), 161. 2018.
その他
2017年
Interview: Aashiq Mirza on the importance of being collaborative for a successful career in academic research. Decoding Life Series. Genes to Genomes. Genetics Society of America.
http://genestogenomes.org/aashiq-mirza-on-the-importance-of-being-collaborative/