Kuroda - Laboratory
略歴
- 1989年
- 東京医科大学卒業
- 1993年
- 東京大学大学院 医学系研究科第3博士課程(医学) 修了
- 1993年
- 東京大学医学部病理学教室文部教官助手
- 1996年
- New York University, Skirball Instituteに癌遺伝子研究のため留学
- 1998年
- 東京医科大学第一病理学講座講師
- 2000年
- JST CREST内分泌攪乱物質研究代表(2005年まで)
- 2002年
- 慶應義塾大学リサーチパーク黒田プロジェクト研究代表
(訪問講師を併任・2005年3月まで)
- 2005年
- 東京医科大学 病理学講座 助教授
- 2009年
- 東京医科大学 分子病理学講座 主任教授
- 2014年
- 東京医科大学 分子病理学分野 主任教授
学位
医学博士
東京大学大学院医学系研究科第3種博士課程(医学)病因病理学専攻
指導教官:町並 陸生教授
資格
- 1989年5月
- 医師免許
- 1992年4月
- 死体解剖資格
- 1995年8月
- 病理専門医
- 2021年
- 分子病理認定医
所属学会・委員
AACR(アメリカ癌学会)
ASCO(アメリカ臨床腫瘍学会)
ASGCT(アメリカ遺伝子細胞治療学会)
ISEV(国際エクソソーム学会)
RNAi研究会
環境ホルモン学会 評議員
日本癌学会
日本病理学会 学術評議員
日本分子生物学会
日本臨床プロテオーム研究会 理事
JSEV(日本細胞外小胞学会)理事
業績
代表論文20編
- Tomohiro Umezu, Masakatsu Takanashi, Yoshiki Murakami, Shin Takeuchi, Takahiro Ochiya, Masahiko Kuroda.
Acerola exosome-like nanovesicles to systemically deliver nucleic acid medicine via oral administration.
Mol Ther Metod & Clin Dev. 2021 Mar 10;21:199-208. doi: 10.1016/j.omtm.2021.03.006. eCollection 2021 Jun 11.
- Saito A, Toyoda H, Kobayashi M, Koiwa Y, Fujii H, Fujita K, Maeda A, Kaneoka Y, Hazama S, Nagano H, Mirza AH, Graf HP, Cosatto E, Murakami Y, Kuroda M.
Prediction of early recurrence of hepatocellular carcinoma after resection using digital pathology images assessed by machine learning.
Mod Pathol. 2021
- Nakaya M, Watari K, Tajima M, Nakaya T, Matsuda S, Ohara H, Nishihara H, Yamaguchi H, Hashimoto A, Nishida M, Nagasaka A, Horii Y, Ono H, Iribe G, Inoue R, Tsuda M, Inoue K, Tanaka A, Kuroda M, Nagata S, Kurose H.
Cardiac myofibroblast engulfment of dead cells facilitates recovery after myocardial infarction.
J Clin Invest. 2017 Jan 3;127(1):383-401. doi: 10.1172/JCI83822. Epub 2016 Dec 5.
- Ohno S, Itano K, Harada Y, Asada K, Oikawa K, Kashiwazako M, Okuyama H, Kumagai K, Takanashi M, Sudo K, Ikeda N, Kuroda M.
Development of novel small hairpin RNAs that do not require processing by Dicer or AGO2.
Mol Ther. 2016 Aug;24(7):1278-89. doi: 10.1038/mt.2016.81. Epub 2016 Apr 25.
- Nakaya T, Ogawa S, Manabe I, Tanaka M, Sanada M, Sato T, Taketo MM, Nakao K, Clevers H, Fukayama M, Kuroda M, Nagai R.
KLF5 regulates the integrity and oncogenicity of intestinal stem cells.
Cancer Res. 2014 May 15;74(10):2882-91. doi: 10.1158/0008-5472.CAN-13-2574.
- Ohno S, Takanashi M, Sudo K, Ueda S, Ishikawa A, Matsuyama N, Fujita K, Mizutani T, Ohgi T, Ochiya T, Gotoh N, Kuroda M.
Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells.
Molecular Therapy.21(1),185-191. doi:10.1038/mt.2012.180. 2013
- Nakaya M, Tajima M, Kosako H, Nakaya T, Hashimoto A, Watari K, Nishihara H, Ohba M, Komiya S, Tani N, Nishida M, Taniguchi H, Sato Y, Matsumoto M, Tsuda M, Kuroda M, Inoue K, Kurose H.
GKR6-deficiency in mice causes autoimmune disease due to impaired apoptotic cell clearance.
Nature Communications.4:1532. doi: 10.1038/ncomms2540. 2013
- Matsubayashi J, Takanashi M, Oikawa K, Mingli Xu, Mukai K, Kuroda M, Mukai K.
Expression of G-protein-coupled receptor kinase 4 is associated with breast cancer tumorigenesis.
J Pathol, 216: 317–327,2008.
- Naoe Y, Setoguchi R, Akiyama K, Muroi S, Kuroda M, Hatam F, Littman DR, Taniuchi I.
Repression of interleukin (IL)-4 in T helper type 1 (Th1) cells by Runx complex through binding to IL-4 silencer.
J Exp. Med., 204:1749-1755, 2007
- Oikawa K, Ishida T, Imamura T, Yoshida K, Takanashi M, Hattori H, Ishikawa A, Fujita K, Yamamoto K, Matsubayashi J, Kuroda M, Mukai K.
Generation of the novel monoclonal antibody against TLS/EWS-CHOP chimeric oncoproteins that is applicable to one of the most sensitive assays for myxoid and round cell liposarcomas.
Am J Surg Pathol , 30:351-6, 2006.
- Kuroda M, Tanabe H, Yoshida K, Oikawa K, Saito A, Kiyuna T, Mizusawa H, Mukai K.
Alteration of chromosome positioning during adipocyte differentiation.
J Cell Sci, 117: 5897-5903, 2004.
- Oikawa K, Ohbayashi T, Kiyono T, Nishi H, Isaka K, Umezawa A, Kuroda M, Mukai K.
Expression of a Novel Human Gene, Human Wings Apart-Like (hWAPL), is associated with cervical carcinogenesis and tumor progression.
Cancer Res, 64: 3545-3549, 2004.
- Oikawa K, Kosugi Y, Ohbayashi T, Kameta A, Isaka K, Takayama M, Kuroda M, Mukai K.
Increased expression of IgE-dependent histamine-releasing factor in endometriotic implants.
J Pathol, 199: 318-323, 2003.
- Oikawa K, Ohbayashi T, Mimura J, Iwata R, Kameta A, Evine K, Iwaya K, Fujii-Kuriyama Y, Kuroda M, Mukai K.
Dioxin suppresses the checkpoint protein, MAD2, by an AhR-independent pathway.
Cancer Res, 61: 5707-5709, 2001.
- Kuroda M, Sok J, Webb L, Baechtold H, Urano F, Yin Y, Chung P, de Rooji DG, Akhmedov AT, Ashley T and Ron D
Male sterility and enhanced radiation sensitivity in TLS-/- mice.
EMBO J, 19: 453-462, 2000.
- Kuroda M, Wang X, Sok J, Yin Y, Chung P, Giannotti J, Jacobs KA, Fitz LJ, Murtha-Riel P, Turner KJ, Ron D.
Induction of a secreted protein by the myxoid liposarcoma oncogene.
Proc Natl Acad Sci USA, 96: 5025-5030, 1999.
- Zou YR, Kottmann AH, Kuroda M, Taniuchi I, Littmann DR.
Function of the Chemokine receptor CXCR4 in haematopoiesis and in cerebellar development.
Nature, 393: 595-599, 1998.
- Zinszner H, Kuroda M, Wang X, Batchvarova N, Lightfoot RT, Remotti H, Stevens JL, Ron D.
CHOP is implicated in programmed cell death in response to impaired function of the Endoplasmic Reticulum.
Genes & Dev, 12: 982-995, 1998.
- Kuroda M, Ishida T, Takanashi M, Satoh M, Machinami R, Watanabe T.
Oncogenic transformation and inhibition of adipocytic conversion of preadipocyte by TLS/FUS-CHOP typeII chimeric protein.
Am J Pathol, 151: 735-744, 1997.
- Kuroda M, Ishida T, Horiuchi H, Kida N, Uozaki H, Takeuchi H, Tsuji K, Imamura T, Mori S, Machinami R, Watanabe T.
Chimeric TLS/FUS-CHOP gene expression and the heterogeneity of its junction in human myxoid and round cell liposarcoma.
Am J Pathol, 147: 1221-1227,1995.